AIS
- Created by: milliehubbard1
- Created on: 21-04-17 10:43
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- Adaptive immune system
- Organ-specific and responds slowly on first presentation
- Cells based in lymphoid tissue require interaction with antigen presenting cells
- Macrophages, dendritic cells and B cells are all APCs
- Dendritic cells bind antigen and move from peripheral to lymphoid tissue
- APCs contain toll-like receptors (TLRs) on their surfaces
- 10 TLRs identified in humans to date - each binds to specific molecular patterns
- TLR activation results in cytokine production to mount an adaptive immune response
- Specialised lymphocytes (B and T cells) contain antigen-specific receptors
- Both B and T cells are produced in the bone marrow and can secrete and respond to cytokines
- Macrophages, dendritic cells and B cells are all APCs
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