NSAIDs
- Created by: Popstar
- Created on: 09-01-14 10:23
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- NSAIDs
- MOA
- inhibits COX
- Prevents production of prostanoids from Arachidonic acid
- Subtypes of Cyclo-oxygenase
- COX-1
- homeostatic control of prostaglandins
- Present in Most Cells
- COX-2
- Expression in inflammatory response
- COXIBS - selective COX-2 inhibitors
- Celecoxib & Etericoxib
- Rofecoxib - withdrawn for serious ADRs
- Adverse Effects
- Less GI effects than traditional NSAIDs
- CV effects
- reduced production of prostaglandin I2 which normally protects against atherosclerosis
- CV Effects
- Increased bleeding due to inhibition of platelet aggregation
- CV Effects
- reduced production of prostaglandin I2 which normally protects against atherosclerosis
- COX-2
- Expression in inflammatory response
- COXIBS - selective COX-2 inhibitors
- Celecoxib & Etericoxib
- Rofecoxib - withdrawn for serious ADRs
- Adverse Effects
- Less GI effects than traditional NSAIDs
- CV effects
- reduced production of prostaglandin I2 which normally protects against atherosclerosis
- CV Effects
- Increased bleeding due to inhibition of platelet aggregation
- CV Effects
- reduced production of prostaglandin I2 which normally protects against atherosclerosis
- COX-3/1b
- Brain & Spinal Chord
- Pain perception
- COX-1
- inhibits COX
- Pharmacological Actions
- Analgesic effect
- Antipyretic effect
- Anti-inflammatory effect
- Strong
- Ketoprofen
- Piroxicam
- Moderate
- Ibuprofen
- Naproxen
- Strong
- Clinical Uses
- Rheumatoid arthritis
- Oesteoathritis
- Other anthropathies
- Acute Gout
- Inflammation pain and tissue injury
- Fever
- Adverse Effects
- GI effects
- ulcers
- NSAIDs contraindicated in ulcer patients
- nausea, vomiting, dyspepsia, abdominal pain
- minimised by co-admin of PPI e.g. omeprazole
- ulcers
- Hypersensitivity Reactions
- Renal Effects
- GI effects
- ASPIRIN
- Salicylate
- 166x more potent at COX1 than COX2
- Therapeutic Effects
- Peripheral& Central effects
- Anti-thrombotic
- Anti-cancer (colon)
- Alzheimer's
- Radiation-induced Diarrhoea
- Analgesic
- Antipyretic
- Anti-inflammatory
- Adverse Effects
- Gestric irritation & haemorrhage
- CNS
- asthma
- Reye's syndrome
- Toxic - metabolic acidosis
- MOA
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