apoptosis (cell death)
- Created by: Amber Manley
- Created on: 16-01-14 12:25
View mindmap
- apoptosis (cell death)
- necrosis
- accidental death following trauma
- cells swell and burst
- contents release and cause inflammation
- trauma, lack of blood
- programmed cell death
- apoptosis
- cells die in organised manner, are engulfed and digested
- requires ATP
- no inflammation
- why need
- proper development
- lose webbing as embryo
- lose tail as tadpole
- proper function
- to form synapses, surplus cells need to die
- destroy cells that are a threat
- cells infected with viruses/bacteria/parasites
- cancer
- DNA damaged
- cytotoxic T cells can induce in other cells
- proper development
- Features
- falling off
- shrinkage of cell and nucleus
- cleavage of nuclear proteins
- condensation of chromatin
- nucleus fragmentation
- cleavage of cytoskeleton
- require ATP
- caspase cascade
- capases are cell death proteases
- synthsised as inactive pro-capases
- activated by each other (cleavage)
- initiator capase activate a cascade generating lots of effector capases
- cleave cellular components
- Intrinsic pathway
- damage or stress
- damaged mitochondria release electron carrier cytochrome c
- cytochrome c in the cytoplasm activates initiator caspase
- initiar caspase causes a cascade
- Extrinsic pathway
- proteins from other cells bind to death receptors
- death receptors aggregate and cause caspase to be cleaved
- activates cascade
- necrosis
Comments
No comments have yet been made