Fluid homeostasis
- Created by: kpritchard16
- Created on: 20-12-18 17:23
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- Fluid homeostasis
- Systems needed to maintain fluid physiology
- renal, vascular, respiratory and GI
- normal ECF osmolarity = 280-300mOsmoles/L
- Stimulations that trigger hypothalamic thirst centre
- decrease in plasma volume
- increase in plasma osmolarity
- baroreceptor input
- Osmolarity values
- At bottom of Loop of Henle = 1200mOsm/L
- In blood = 300 mOsm/L
- In urine = 50-1200mOsm/L
- Hormone used
- Vasopressin - activates aquaporins, secreted frm posterior pituitary
- Primary brain osmoreceptor lies outside BBB
- What happens if dehydration occurs
- 1. Increase in osmolarity directly inhibits aldosterone secretion by zona glomerulosa in adrenal cortex
- 2.Decrease aldosterone
- 4. Decrease in osmolarity
- 3. Decrease sodium ion reabsorption
- Hyperhydration - temporary excess of water
- Hyponatremia - deficient sodium in blood
- Symptoms: vomiting, headache, muscle weakness, fatigue, confusion
- Treatment - Diuretics
- Systems needed to maintain fluid physiology
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