Johne's Disease

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  • Johne's Disease
    • Definition
      • chronic enteritis - M.paratuberculosis
      • small intestines and ileum thickening
      • carrier ---> subclinical --> clinical
      • Sources
        • faeces from shedding cattle/ sheep
        • colostrum/milk from infected cattle
        • environment
      • develop 2-6yo
    • Clinical signs
      • diarrhoea
      • decreased production
      • weight loss
      • oedema
    • DDx
      • nutritional problem
      • liver fluke
      • LDA
      • parasitic gastroenteritis
      • salmonellosis
      • peritonitis
    • Diagnostics
      • detect MAP
        • shedding not until later disease
        • can use pooled sample
        • faecal culture- good detection but £££
        • faecal PCR- good if its present
      • detect immune response
        • only Ab evaluation available
        • more sensitive early infection
    • Treatment
      • none- needs management
      • usually cull ASAP
    • prevention/manage
      • transmission
        • sepearte youngstock up to 1yo from source
        • main focus in herds that tes +ve
      • biosecurity
        • prevent buying in
        • know sources for buying
        • test individuals
        • keep closed herd
      • test and cull - blood Ab
      • identify high risks - individual milk sample Ab testing - cull high risk
      • Vaccination
        • prevent disease not infection
        • can import vaccine with license
        • may interfere with TB test
      • Untitled

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