Aim: to explain the behaviour of a large family where the males are affected by a syndrome of borderline mental retardation and abnormal violent behaviour; impulsive aggression, arson, attempted ****, and exhibitionism.
Sample: 5 affected males from same Deutsch family
Method: Case study - data were collected from analysis of urine samples over 24hr period
Key Results: tests show disturbed monoamine metabolism associated with deficit of enzyme monoamine oxidase A (MAOA). In each of the 5 males, point mutation was identified in the X chromosome of the gene responsible for production of MAOA
Conclusions: MAOA is involved in seretoin metabolism. Deficit in gene (leading to impaired seretoin metabolism) responsible for mental retardation in family. MAOA deficiency in family associated with a recognisable behaviourable phenotype - inability to regulate aggression. Not all of the males affected by violent behaviour.
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