Inhibitors.

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Inhibitors.

  • Slow down rate of reaction of enzyme when necessary (e.g. when temp is too high)
  • Molecule present in highest conc. is most likely to form an ES-complex
  • Competitive inhibitors:
    • Compete with substrate
    • Shape similar to substrate/prevents access when bonds
    • Can slow down metabolic pathway
  • Non-competitive inhibitors:
    • Chemical does not have to resemble the substrate
    • Binds to enzyme other than at active site
    • This changes the enzyme's active site and prevents access to it
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