what are the symptoms of systemic lupus erythematosus
ulcers, aches, poor circulation, inflammation in pericardium, pleura. butterfly rash, fatigue, loss of appetite , low grade fever, photosensitivity
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pernicious anaemia- talk about autoantibodies
autoantibodies are directed against IF. so this prevents interaction with Vit B12 which would normally be absorbed as a complex with IF
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when does immunopathological damage occur
when. autoAg is localised to a particular organ. type II hypersensitivity and cell mediated reactions - damage due to complement activation and phagocyte degranulations
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pt 2
Immune complexes appear to be pathogenic in systemic autoimmunity, Type III hypersensitivity reactions, Acute tissue damage
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talk about the pathology of rheumatoid arthritis
Inflammatory infiltrate found in synovial membrane Erosion of synovial cartilage and bone IC and neutrophils present in joint space IC can arise through self association of rheumatoid factors = IgG molecules with unusual oligosaccharides
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what is cicatricial pemphigoid
(mucous membrane pemphigoid/benign pemphigoid) Chronic autoimmune disease of mucosal membranes and/or skin Lining of mouth common site of involvement
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what is Sjögren’s syndrome
Chronic inflammatory autoimmune disorder, Characterised by a lymphocytic infiltrate in salivary and lacrimal glands, Slow destruction and replacement of glandular tissue with fibrotic tissue, Lack of saliva and tear secretion
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what are some of the treatment of autoimmune disorders
metabolic control , Anti-inflammatory drugs, Immunosuppressive drugs , Monoclonal antibodies to blockade certain cytokines or their receptors
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Other cards in this set
Card 2
Front
What do auto reactive antibodies and T cells
Back
develop these recognise self antigens
Card 3
Front
what happens to antibodies in Hashimoto's thyroiditis
Back
Card 4
Front
What do acinar epithelial cells do in normal thyroid gland
Back
Card 5
Front
what destroys and replaces normal thyroid gland for it to turn to hashimato thyroid gland
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