cell singling pathways

?
how do cells comm with each other
electrical and chemical comm
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what is phosphatase for
dephophoralation
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what are the activators of cellular responses/ primary messenger / cell stimuli
Growth factors: EGF, TGFa, TGFb, FGF etc. Hormones: Insulin, Cortisol etc. Extracellular matrix molecules: Fibronectin, Laminin etc. Drugs Chemicals what
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What are the mechanisms that can cause disease
Losing the signal When a signal doesn’t reach its target When the target ignores the signal Too much signal Multiple breakdowns
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what are the hallmarks of cancer
resisting cell death, inducing angiogenesis, enabling replicative immortality, sustaining proliferative signaling, activating invasion and metastasis, evading growth suppressors and sustaining proliferative signaling
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what does the EGF fam do
Promotes cell proliferation in oral tissues.Stimulates target cell by binding to the epidermal growth factor receptor (EGFR
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Talk about TGF beta 1,2,3. what does it associate with
TGF-β 1, 2 plays important role in cancer but TGF-β 3 has a role in development. Associates with more aggressive disease and worse survival
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what does a decrease of FGFR 3 levels mean
A decrease of FGFR3 levels in HNSCC leads to a 35% reduction in proliferation in vitro
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what is phosphatase for

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dephophoralation

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what are the activators of cellular responses/ primary messenger / cell stimuli

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What are the mechanisms that can cause disease

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what are the hallmarks of cancer

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