4. Give a characteristic of neutrophils and give the main role
4. Multilobed nucleus. They adhere to endothelial cells lining blood vessels and squeeze between them to leave circulation and enter tissues (diapedesis). Predominant role- phagocytosis and destruction of pathogens
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5. What do the granules of the neutrophil contain?
5. Arsenal against microbes: lysosomes- acid hydrolase, myeloperoxidase, lysozyme, defensins. Secondary granules : lactoferrin and lysozyme
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6. Eosinophil characteristics
6. Bilobed nucleus, granules stain with eosin. Basic protein. Release of granules upon activation- killing of large pathogens that cannot be phagocytosed
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7. Main role of basophils
7. Triggered by allergens to release contents of their granules
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8. What re macrophages dereived from ?
8. From yolk sac precursors
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9. Examples of accessory cells:
9. Platelets, ACP, mast cells, endothelial cells
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10. What are the roles of endothelial cells
10. Receptors recognise certain lymphocytes, comtrol lymphocyte traffic and distribution
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11. Role of apc
11. Produce cytokines (which stimultate NK +B cells) + present antigens to t cells
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12. What re the orprimary and secondary lymphoid organs?
12. 1ry: thymus, bone marrow – produce b and t cells 2ry: waldeyer’s ring (tonsils and adenoid) lymphoid nodules, lymph nodes , peyer’s matches , spleen, bronchus associated lymphoid tissue
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13. What cell is shown by CD8, CD20
13. Tc, B cell
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14. Whats clonal expansion ?
14. When more cells are activated and more memory cells produced
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