Due to alcoholism: Poor diet and impaired absorbtion of thiamine from intestine, produces bilateral degeneration of mamilarly bodies
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What happens in a temporal lobectomy?
Patients who had intractable seizures, bilateral removal of the temporal lobes
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What happened to Patient HM?
Major seizure since 16, drugs failed to contain seizures so had surgical removal of anterior hippocampal regions
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What did the surgery lead to?
No affected IQ or personality, but there were deficits in specifics to the formation of new memories
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What could HM not recall?
reported Date and age as prior to the operation, could not remember events or people met since the operation, could not learn location of new home, hippocampus important in spatial learning
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What happened to the sematic memory?
incompletely disrupted, language was frozen in the 50s
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What happened to his working memory/
repeat a sequence, rte of forgetting in moral range, cant hold a conversation but forget ever holding it
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What happened to HM's procedural memory?
can learn a new motor task, normal improvement on mirror tracing task
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What is retrograde amnesia?
prior to lesion, loss of memory and access to events that occured before an injury
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HOw did Hm have temporary retrograde amnesia?
old childhood memories were okay, memories immediately before lesion lost, forget death of favourite uncle in 1950s
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What does studying HM suggest about the hippocampus?
It does not store memories, old memories are preserved
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What is the role of the hippocampus?
not completely understood, consolidation of new memories which are stored else where
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How do they test retrograde amnesia?
HM photos of celebrities suggest retrograde amnesia spans decades with more distant memories relativelypreserved
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What is dissassociation?
some tasks are impaired and others are spared, these tasks use different resources
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