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Why can't large organisms use diffusion to exchange materials?

What do organisms have to exchange materials efficiently?

What are some features of specialised exchange surfaces?

Specialised exchange surfaces being thin present what problem?

How is this problem overcome?

Single-celled organisms exchange oxygen and carbon dioxide how?

Why is this possible?

If a cell wall is present in a single-celled organism is this a barrier to diffusion?

The large surface area of insects for exchange conflicts with what?

What do insects have in their cuticle?