Hypersensitivity reaction initiated by antibody-mediated or cell-mediated immunological mechanisms but not defined on the basis of an increased level of IgE
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Hypersensitivity
Objectively reproducible symptoms or signs initiated by exposure to a defined stimulus or dose which is tolerated by a normal person.
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Allergen
Molecule that induces IgE mediated immunity in humans.
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Major Allergen
>50% patients recognise
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Class 1 allergen
Stable to heat, acid, proteases, causing symptoms related to primary sensitisation
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Class 2 allergen
Not stable and causes symptoms due to cross reactivity
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Epitope
Part of the allergen's amino acid sequence recognised by the antibody; can be linear or conformational
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IgE mediated
Used when the antibody involved is part of the IgE isotope
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Non-IgE mediated
Mediated by allergen-specific lymphocytes, as in allergic contact dermatitis, or antibodies of the IgE isotope
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Non-Allergic Hypersensitivity
Involves other proteins and is reproducible
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Cross-Reactivity
e.g Birch pollen and apple. Antibodies produced by one allergen may bind with a structurally similar/homologous epitope from another allergen
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Other cards in this set
Card 2
Front
Objectively reproducible symptoms or signs initiated by exposure to a defined stimulus or dose which is tolerated by a normal person.
Back
Hypersensitivity
Card 3
Front
Molecule that induces IgE mediated immunity in humans.
Back
Card 4
Front
>50% patients recognise
Back
Card 5
Front
Stable to heat, acid, proteases, causing symptoms related to primary sensitisation
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