Immuno lec 17 Immunce cell trafficking 0.0 / 5 ? Biologyimmuno3rd yearUniversityAll boards Created by: AmhCreated on: 01-01-17 15:46 Do innate or adaptive immune cells have to be trafficked? Both need to be trafficked, need to get from bone marrow to target 1 of 20 How are immune cells trafficked Multi-step paradigm of leukocyte extravasation 2 of 20 what are the steps in this 1. Tethering and rolling 2. Activation 3. arrest 4. Diapedesis 3 of 20 What molecules are involed in tetherins and rolling Selectins 4 of 20 What do selectins signal chemokines and integrins 5 of 20 What is the primary molecule involved in activation chemokines 6 of 20 What are some CAMs selectins, mucins, integrins, Ig superfamily members ` 7 of 20 What are the selectins that mediate tethering and rolling C-type lectins family composed of L selctins E selectins an P selectins 8 of 20 What do the lectin domains of these selectins bind Bind specific carbs (sialyl lewis) groups 9 of 20 How are sialyl lewis residues added o proteins glycosyltransferase enzymes 10 of 20 Which c tye lectins will be on endothelial cells P and Eselectins 11 of 20 which c type lectin mediates its effect from the leukocyte L selectin 12 of 20 Why are c type lectins important they are responsible for the initial stickiness, and their ativation induces chemojine signals 13 of 20 where does the 'rolling' come from there is a rapid on and off nteraction 14 of 20 what stimulates this binding in the first place catch bonds 15 of 20 what is arrest mediated by integrins 16 of 20 How is arrest mediated integrins 17 of 20 what are integrins heterodimeric proteins composed of Large a & smaller b chains linked non-covalently 18 of 20 what do integrins bind to Ig superfamily CAMs and cell matrix proteins 19 of 20 How do chemokines effect integrins they induce a conformational change in integrins , 20 of 20
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