Immunology- Immunodeficiency

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  • Created by: Ruth
  • Created on: 08-02-13 13:50
How does somone become immuncompromised?
Through an immune deficiency
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What type of deficiency are bacterial infections consistent with?
B lymphocyte and antibody
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What type of deficiency are viral infections consistent with?
T cell deficiency
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What other infections are consistent with T cell deficiency?
Fungal, intracellular bacterial
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What are the two categories of immune deficiency?
Primary and secondary
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Name some primary immunedeficiencies
Di Georges, SCID, CHronic garanulomatous disease, X linked IPEX, X linked Hyper IgM syndrome, selective IgA deficiency
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What is chronic granulomatous disease?
Failure to kill pathogens ingested by phagocytes
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What is the gene?
Gene for NADPH oxidase
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What is Di george syndrome?
UNdeveloped/missing thymus
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X linked hyper IgM syndrome
Mutation in CD40L or NEMO leads to no class switching and therefore no secondary antibody response
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X linked IPEX
Defective Foxp3 which is a transcription factor inTtreg. This is an immundeficiency dependent autoimmune disease
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WHat is SCID?
Severe combined immune deficiency, effects B and T cells so they have no response to ILs.
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WHat are the genes in SCID?
Mainly Jak3 or gamma c.
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WHat is leukocyte adhesiondeficiency caused by?
beta2 integrin defect
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What are some of the common causes of secondrary immune deficiency?
Malnutrition, cytotoxic drugs and radiation, diabetes, infections, tumours
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What are the common treatments for immunedeficiency?
Antibiotics, gammagoulins for antibody deficiency, cell replacement and gene therapy
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Card 2

Front

What type of deficiency are bacterial infections consistent with?

Back

B lymphocyte and antibody

Card 3

Front

What type of deficiency are viral infections consistent with?

Back

Preview of the front of card 3

Card 4

Front

What other infections are consistent with T cell deficiency?

Back

Preview of the front of card 4

Card 5

Front

What are the two categories of immune deficiency?

Back

Preview of the front of card 5
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