Inflammation and Wound Repair

Causes of acute inflammation.

Trauma, surgery, burns, chemicals,
infection, necrosis, foreign body, allergic reaction

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4 stages that occur in response to tissue injury.

Hemostasis, inflammation, proliferation and remodelling.

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What is the purpose of acute inflammation

defence: white bloods cells leucocytes to the area
promotes repair of damaged tissue

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what are the 5 signs of acute inflammation

pain, redness, swelling, heat, loss of function

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In cellular invasion what is the first cell to arrive

Neutrophils- role phagocytosis: remove bacteria and debris, release additional signalling to macrophages

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what controls inflammatory response

prostaglandins, cytokines, chemokines interleukins.

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what is the purpose of proliferation and remodelling

Purpose: Reparative
Increase in resident cell number
Secretion of new tissue matrix

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what are the key features of proliferation

Key features:

Fibroblast migration to the wound

Collagen synthesis by fibroblasts- granulation tissue

Angiogenesis: formation of new blood vessels

Contraction: wound closure

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what are the possible outcomes of chronic inflammation

Resolution
Regeneration of normal tissue with limited injury
Removal of stimulus
Normalization of vascular permeability
Apoptosis of inflammatory cells
Restoration of normal function

Repair
Repaired with granulation tissue
repaired with granulated tissue

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what are the causes of chronic inflammation

cardiovascular disease, cancer, arthritis, chronic fatigue, lupus, neurological disease

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Inflammation and Wound Repair

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