Genetic association is the association between disease or trait and a genotype or allele of a known marker using population or family data.
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Define Linkage
Linkage describes for two (or more) markers in close enough proximity to one another on the same chromosome to have a recombination frequency of less than 50% (θ
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HWE
the equilibrium state of allele frequencies at a single locus in a randomly mating diploid population
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HWE assumptions
No genetic drift, large population, random mating, males and females share allele frequencies, no mutation or migration, no natural selection for genotypes
Rare recombination - alleles are associated in the population
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Polymorphism
Common genetically determined variation, MAF >0.01
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Card 2
Front
Define Linkage
Back
Linkage describes for two (or more) markers in close enough proximity to one another on the same chromosome to have a recombination frequency of less than 50% (θ
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