NAD+ regeneration, fate of pyruvate and the link reaction 0.0 / 5 ? BiologyBiochemistryUniversityNone Created by: TaraCBeckworthCreated on: 25-08-18 16:22 What is required in order for NAD+ to be regenerated? Oxygen 1 of 14 What 2 reactions occur in order to regenerate NAD+ under low O2 conditions? Lactic acid fermentation and ethanolic fermentation 2 of 14 What is the enzyme involved in lactic acid fermentation? Lactate dehydrogenase 3 of 14 Describe NAD+ regeneration through lactic acid fermentation Pyruvate is reduced to lactic acid by 2H from NADH+H, creating NAD+ 4 of 14 What happens after the NAD is regenerated? The lactic acid is transported to the liver to be metabolised into pyruvate which is further metabolised to glucose through gluconeogenesis 5 of 14 What enzymes are involved in ethanolic fermentation? Pyruvate decarboxylase and alcohol dehydrogenase 6 of 14 Describe ethanolic fermentation Pyruvate goes through a decarboxylation reaction then an oxidising/reducing reaction (intermediate product: acetaldehyde) 7 of 14 What are the metabolic fates of pyruvate? Reduction of pyruvate allows regeneration of NAD+ for glycolysis, conversion of pyruvate to acetyl CoA for the complete oxidation of glucose 8 of 14 Describe the link reaction Oxidative decarboxylation of pyruvate, pyruvate reacts with CoA, 3 ATP per pyruvate 9 of 14 What enzyme is involved in the link reaction? Pyruvate dehydrogenase 10 of 14 Is the link reaction reversible or irreversible? Irreversible 11 of 14 What is the product of the link reaction? Acetyl CoA (1 per pyruvate molecule) 12 of 14 What happens to the acetyl group of pyruvate? It is transferred to CoA-SH 13 of 14 Which group is the reactive part of acetyl-CoA? The thiol group 14 of 14
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