Pharmacodynamics

?
  • Created by: ntygs19
  • Created on: 15-03-20 19:39
What is pharmacology the science of?
Proporties of drugs and their effects on the body
1 of 29
Define the term Pharmacodynamics
The physiological effects of the drug and their mechanisms of action
2 of 29
Define Pharmacokinetics `
The physiological processes that effect the concentration of the drug in the body
3 of 29
Which one is 'what the body does to the drug' and which one is 'what the drug does to the body'?
Pharmacokinetics = what the body does to the drug. Pharmacodynamics = what the drug does to the body
4 of 29
What is the difference between Indication and Contraindication?
Indication = the condition/illness which the drug is prescribed for (what INDICATES need for drug). Contraindication = when a drug is NOT recommended for use in a particular condition (e.g. allergies)
5 of 29
What does the term 'caution' relate to?
When you have to be careful about giving a drug to a particular group of people (e.g. children, pregnant people)
6 of 29
PHARMACODYNAMICS
See next
7 of 29
Drugs simply i_ with preexisting biological mechanisms and pathways.
interact
8 of 29
DRUG TARGETS (Pharmacodynamics)
See next
9 of 29
What are the 4 major groups of drug targets? 1) E_, 2) R_ R_; 3) I_ C_; and 4) C_
1. Enzymes; 2) Regulatory Receptors 3) Ion Channels; 4) Carriers
10 of 29
Outline the simple scheme of biological pathways... by m_ pathway, a molecule (e.g. sugar) is b_ d_ by an e_ into smaller molecules (e.g. Glucose and Fructose)
By METABOLIC pathway, a molecule (e.g. sugar) is BROKEN DOWN by an ENZYME into smaller molecules (e.g. Glucose and Fructose)
11 of 29
What is the function of enzymes?
Shape speciifc, catalyse biological pathways and metabolise certain molecules
12 of 29
Enzymes are catalysts... what does this mean?
They speed up metabolic reactions
13 of 29
An enzyme's shape speicifc active site can only interact with molecules of a specific s_
An enzyme's shape speicifc active site can only interact with molecules of a specific SHAPE
14 of 29
What is the main hypothesis related to metabolisation of drugs?
Lock and Key hypothesis
15 of 29
Binding site is also known as A_ site
Active Site
16 of 29
What is the 'lock' and what is the 'key' of the lock and key hypothesis?
Lock = active site. Key = molecule
17 of 29
Binding sites are specific to what?
Shape
18 of 29
For a drug to be therapeutically useful, it must act s_ on particular cells. This means they must show a high degree of B_ S_ s_
For a drug to be therapeutically useful, it must act SELECTIVELY on particular cells. This means they must show a high degree of BINDING SITE SPECIFICITY
19 of 29
REGULATORY RECEPTORS (Pharmacodynamics)
See next
20 of 29
What are the function of regulatory receptors? Where are they located? What are they activated by?
Located on outside of cell. Changes activity of the cell when activated by things like hormones.
21 of 29
Are they shape specific?
Yes
22 of 29
How do drugs interact with regulatory receptors?
Drugs can be created to mimic the shape of activating molecules (e.g. hormones) to turn the regulatory receptors on and off.
23 of 29
What would a drug with agonistic effects do to a regulatory receptor site?
Turn it on
24 of 29
What would a drug with antagonistic effects do to a regulatory receptor site?
Turn if off
25 of 29
What are ion channels? What do they do?
Little pores through the cell membrane which allow ions to move in and out. Shape specific
26 of 29
How do drugs affect ion channels?
Blocking these channels
27 of 29
What are carriers? What do they do?
Carry shape specific molecules in and out a cell by spinning it around and ejecting it in/out of the cell.
28 of 29
How do drugs affect ion channels? 2 ways
1. Blocking it preventing
29 of 29

Other cards in this set

Card 2

Front

Define the term Pharmacodynamics

Back

The physiological effects of the drug and their mechanisms of action

Card 3

Front

Define Pharmacokinetics `

Back

Preview of the front of card 3

Card 4

Front

Which one is 'what the body does to the drug' and which one is 'what the drug does to the body'?

Back

Preview of the front of card 4

Card 5

Front

What is the difference between Indication and Contraindication?

Back

Preview of the front of card 5
View more cards

Comments

No comments have yet been made

Similar Nursing resources:

See all Nursing resources »See all Pharmacology resources »