Pharmacology 2A 0.0 / 5 ? OtherFIUniversityNone Created by: ANNAVANDERSTAPCreated on: 18-11-19 10:19 What units is Kd given in? Molar 1 of 33 What shape is the shape of the graph for fractional occupancy against concentration? Rectangular hyperbola 2 of 33 What is Kd a measure of? Affinity 3 of 33 What is the symbol for the rate constant from the inactive to the active drug receptor complex β 4 of 33 What is intrinsic efficacy? The number the drug displays to switch the drug molecule from inactive to active 5 of 33 Which will always be bigger, Kd or EC50? Kd 6 of 33 Kd/EC50 gives a rough estimate for what? Receptor reserve 7 of 33 Propranolol is a.... Antihypertensive drug 8 of 33 Adrenaline acts on.... β 1 receptors 9 of 33 Haloperidol is a .... Antipsychotic 10 of 33 Haloperidol works on.... D2 receptors 11 of 33 Ranitidine works on which receptor? H2 12 of 33 Which drug acts at alpha 1 receptors on the pupil to cause dilation? Noradrenaline 13 of 33 Acetylcholine causes constriction of the pupil by acting on which receptors? Muscarinic 14 of 33 What is the name for when a receptor cycles between inactive and active even without anything bound to it? Constitutive activity 15 of 33 How long roughly does a receptor last on the membrane? 4 hours 16 of 33 What is the symbol for the hill coefficient n 17 of 33 What does L* indicate The radioactivity of the ligand 18 of 33 What does the Cheng Prusoff method allow you to estimate? Ki 19 of 33 What structure does the nicotinic acetylcholine receptor have? Pentameric 20 of 33 Which subunit does the acetylcholine bind to in the muscle nicotinic acetylcholine receptor? Alpha 21 of 33 Which ion flows the most through the muscle nicotinic acetylcholine receptor? Sodium 22 of 33 Which ion flows the most through the neuronal nicotinic acetylcholine receptor? calcium 23 of 33 What structure is the P2X receptor? Trimeric 24 of 33 Where do allosteric ligands bind on the GABAa receptor? between the alpha and gamma sites 25 of 33 What is neostigmine? A cholinesterase inhibitor 26 of 33 NO711 blocks the take of which transmitter? GABA 27 of 33 D-tubocurarine is a competitive antagonist at which receptor in the periphery? nAChR 28 of 33 How is choline generated? Consumed in the diet 29 of 33 Are the Muscarinic or the nicotinic AChR important in rest and digest? Muscarinic 30 of 33 Toxins from food poisoning can cause what as a result of binding presynaptically at the NMJ? Tetanus 31 of 33 Botulin toxin is used medically to relieve spasticity and to... Decrease saliva production 32 of 33 What is the name of the molecule that is required to take up acetate and choline presynaptically? Hemicholium 33 of 33
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