The lobes develop from 2 embryologically distinct ectodermal tissues - Posterior lobe arises from an invagination of the diencephalon (forebrain). An outgrowth from the roof of the mouth known as Rathke's pouch forms the anterior pituitary lobe
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What controls the PL?
Neuronal projections from the brain - in particular the supraoptic nucleus and paraventricular nucleus
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What controls the AL?
Hypothalamic hypophysiotrophic hormones, feedback loops from target glands, circadian rhythms, seasonal rhythms and reproductive cycles
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What were the effects of the hypophysectomies performed by Smith on rats in the 1930s?
Stopped lactation and growth; led to atrophy of the adrenal gland, gonads, and thyroid; disturbed salt/water balance, carbohydrate and protein metabolism; ultimately led to their deaths
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Why was it realised that the PG is not autonomous?
Brain lesion studies showed changes in pituitary gland hormone levels indicating influence of the central nervous system
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What are the five different endocrine cell types in the AL?
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