SPECIALIST COMMUNITY PUBLIC HEALTH NURSING 5 0.0 / 5 ? MedicineSCPHNUniversityNone Created by: carol.morrisonCreated on: 10-08-14 10:14 METABOLISM USUALLY OCCURS CHIEFLY IN THE LIVER IF LIVER IS IMPAIRED OTHER ORGANS MAY TAKE OVER, OTHER SITES WHERE METABOLISM WILL OCCUR ARE GASTRO-INTESTINAL TRACT, KIDNEY, MUSCLE, BRAIN, NERVES 1 of 7 METABOLISM IS EFFECTED BY..... HEPATIC BLOOD FLOW, ENZYME ACTIVITY CYTOCHROME P450, THE NUMBER OF HEPATOCYTES (CELLS) 2 of 7 CYTOCHROME P450 IS...... A MAJOR HEPATIC ENZYME IN THE LIVER THAT CAN BE SPEED UP OR SLOWED DOWN 3 of 7 ST JOHNS WORT...... SPEEDS UP CYTOCHROME P450 AND REDUCES THE EFFECT OF THE DRUG IN THE BLOOD EG CONTRACEPTIVES 4 of 7 GRAPEFRUIT..... SLOWS DOWN THE EFFECT OF THE DRUG IN THE BLOOD AND INCREASES ITS HALF LIFE AND RISK OF TOXICITY 5 of 7 FIRST PASS EFFECT IS...... DRUG GOES INTO THE CIRCULATION AND PASSES THE HEPATIC VEIN TO THE LIVER 6 of 7 METABOLISM OF DRUGS IS.... ALL THE PHYSICAL AND CHEMICAL CHANGES WHICH LEAD TO THE BREAKDOWN OF THE DRUG OR CHANGE IT TO A DIFFERENT SUBSTANCE (METABOLITES) 7 of 7
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