The Tricarboxylic Acid Cycle 0.0 / 5 ? BiologyBiochemistryUniversityNone Created by: TaraCBeckworthCreated on: 25-08-18 17:04 What is the tricarboxylic acid pathway otherwise known as? The Krebs cycle 1 of 14 What is the starting product? Acetyl-CoA from the link reaction 2 of 14 How many turns of the cycle is it per molecule of glucose? 2 as there is 2 pyruvate molecules from 1 glucose meaning 2 link reactions and 2 turns of the cycle 3 of 14 Step 1 Condensation reaction, Acetyl CoA joins with oxaloacetate, (Enzyme: Citrate synthase), product: Citrate 4 of 14 Step 2 Rearrangement, successive dehydration, removing water then re-adding it, (Enzyme: Aconitase), product: Isocitrate 5 of 14 Step 3 Oxidative decarboxylation, NAD+ reduced, CO2 released, (Enzyme: Isocitrate dehydrogenase), cofactor: BMn2+, product: a-ketoglutarate 6 of 14 Step 4 Oxidative decarboxylation, NAD+ reduced, CO2 released, (Enzyme: a-ketoglutarate dehydrogenase), Coenzyme: CoA-SH, Cofactor: Mg2+, product: Succinyl-CoA 7 of 14 Step 5 Hydrolysis reaction, CoA is lost, (Enzyme: Succinyl-CoA synthase), 1 ATP produced, cofactor: Mg2+, product: succinate 8 of 14 What are steps 6,7 and 8 purpose? To regenerate oxaloacetate in order to make it a complete cycle 9 of 14 Step 6 Oxidation, 1 FAD reduced, takes place in inner mitochondrial membrane, (Enzyme: Succinate dehydrogenase), product: Fumerate 10 of 14 Step 7 Hydration reaction, (Enzyme: fumerase), product: Malate 11 of 14 Step 8 Oxidation, NAD+ as hydrogen carrier so 1 reduced NAD+, 3 ATP, (Enzyme: Malate dehydrogenase), product: oxaloacetate 12 of 14 What is the ATP yield from one turn of the TCA cycle? 12 ATP molecules (11 ATP from oxidative phosphorylation, 1 ATP from substrate level phosphorylation) 13 of 14 What is the over all yield of ATP per 1 molecule of glucose? 38 ATP molecules (8 from glycolysis, 6 from link reaction, 24 from TCA cycle- from 1 molecule of glucose) 14 of 14
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