Ubiquitin Tagging for Protein destruction 2.0 / 5 based on 1 rating ? BiologyUniversityOther Created by: jessicaCreated on: 18-12-12 14:07 What happens in the first step? The terminal carboxylate of ubiquitin links to the sulphurhydryl group of ubiquitin activating enzyme by a thioester bond. 1 of 5 What happens in the second step? The activated ubiquitin is shuttled to sulphurhydryl group of the ubiquitin conjugating enzyme 2 of 5 What happens in the third step? Ubiquitin protein ligase catalyses transfer of ubiquitin from the ubiquitin conjugating enzyme to an E-amino group on the target protein 3 of 5 What are the three enzymes used in ubiquitin tagging? Ubiquitin activating enzyme, Ubiquitin conjugating enzyme, Ubiquitin protein ligase 4 of 5 What happens to the protein when ubiquitin is binded to it? It is marked for destruction by phagocytes or myocytes 5 of 5
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